Lymphoma development and survival in refractory coeliac disease type II: Histological response as prognostic factor
نویسندگان
چکیده
منابع مشابه
Coeliac disease and lymphoma.
Following the original description of lymphoma complicating coeliac disease [1], it has become clear that patients with coeliac disease have a 50to a 100-fold increased risk of developing malignant lymphoma compared with the general population [2,3]. The exact risk is unknown as the precise prevalence and incidence of coeliac disease in the population is also unknown. Lymphoma may present in tw...
متن کاملCOELIAC DISEASE Refractory coeliac sprue is a diffuse gastrointestinal disease
Background: Refractory coeliac sprue (RCS) with an immunophenotypically aberrant clonal intraepithelial lymphocyte (IEL) population is considered a cryptic form of intestinal T cell lymphoma. Aims: To investigate the distribution of the abnormal and monoclonal IEL population in the digestive tract of RCS patients. Patients and methods: We compared the frequency of lymphocytic gastritis (LG) and...
متن کاملSevere Refractory Coeliac Disease with Response Only to Parenteral Nutrition
Refractory coeliac disease (RCD) is characterised by recurrent or persistent malabsorptive symptoms and villous atrophy, despite strict adherence to a gluten-free diet for at least 6 months and where other causes of malabsorption including malignancy have been excluded. There is limited evidence and guidance on the effective management of these patients. We describe a case of severe RCD in our ...
متن کاملSurvival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience.
BACKGROUND Coeliac disease may be regarded as refractory disease (RCD) when symptoms persist or recur despite strict adherence to a gluten-free diet. RCD may be subdivided into types I and II with a phenotypically normal and aberrant intraepithelial T-cell population, respectively. RCD I seems to respond well to azathioprine/prednisone therapy. RCD II is usually resistant to any known therapy a...
متن کاملT-cell repertoires in refractory coeliac disease
OBJECTIVE Refractory coeliac disease (RCD) is a potentially hazardous complication of coeliac disease (CD). In contrast to RCD type I, RCD type II is a precursor entity of enteropathy-associated T-cell lymphoma (EATL), which is associated with clonally expanding T-cells that are also found in the sequentially developing EATL. Using high-throughput sequencing (HTS), we aimed to establish the sma...
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ژورنال
عنوان ژورنال: United European Gastroenterology Journal
سال: 2017
ISSN: 2050-6406,2050-6414
DOI: 10.1177/2050640616646529